Stroke is a major research focus for our group and GEMRIC scientists and collaborators use a range of rodent focal cerebral ischaemia models (permanent & transient MCAO). We have a strong focus on translational research where we use a mixture of imaging techniques (MRI & Laser Speckle) as well as behavioural testing, histology and molecular techniques for understanding mechanisms.
Research goals are to identify those mechanisms responsible for inducing brain damage during ischaemia and reperfusion, and subsequent mechanisms promoting repair and recovery. This includes testing new drugs and therapies developed to treat acute stroke and developing better MRI-based diagnostic tools to detect potentially salvageable penumbral tissue. Some of these findings have been developed with significant investment from the Wellcome Trust and private investors into a spin out company, Aurum Biosciences (www.aurumbiosciences.com).