Bruker BioSpec Avance IIIHD 7T  Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) system

7T (300 MHz), 30 cm bore size

Gradient inserts for rat and mouse

Equipped for X-nuclei MR

Capabilities

The system can be used to non-invasively produce many different types of images in animals up to the size of a rabbit. These include:

• ‘Conventional’ MR images based on T₁, T₂ or proton density. These are used to show anatomical detail.
• Blood flow in arteries or veins (magnetic resonance angiography or MRA)
• Blood perfusion through tissue, giving cerebral blood flow and cerebral blood volume maps
• Blood volume in tissue using contrast agents
• Molecular diffusion of water through tissue such as white matter tracts (tractography and diffusion tensor imaging or DTI)
• Relative degrees of bound and unbound water (magnetisation transfer contrast or MTC)
• Tissue movement, such as motion of the heart to yield measures of ejection fraction and myocardial wall motion
• Tissue temperature
• fMRI: Oxygenation of blood (BOLD) to show areas of brain activated by stimuli
• fMRI: cerebral blood volume changes
• resting-state fMRI
• Changes in blood perfusion through tissues in response to pharmacological intervention (phMRI)
• Spectroscopy and spectroscopic imaging
• Intracellular pH of tissue
• Fluorine (19F) MRI