Paterson, S.Holmes, W. and Rodgers, J. (2022) Serial magnetic resonance imaging of splenomegaly in the Trypanosoma brucei infected mouse. PLoS Neglected Tropical Diseases, 16(12), e0010962.

Al-Mubarak, HF, Vallatos A, Holmes WM. “Evaluating potential of multi-parametric MRI using co-registered histology: Application to a mouse model of Glioblastoma.”. Magnetic Resonance Imaging. 2022; 85:121-127



Mohammed S. Alshuhri, Lindsay Gallagher, Lorraine M Work and William M. Holmes. “Direct imaging of glymphatic transport using H217O MRI”.  Journal of Clinical Investigations Insights. 2021; 6: e141159

Barron HC, Mars RB, Dupret D, Lerch J, Sampaio-Baptista C. Cross-species neuroscience: closing the explanatory gap. Phil Trans Roy Soc B 2021: 376(1815): 20190633

Al-Mubarak, HF, Vallatos A, Holmes WM. “Impact of turbulence-induced asymmetric propagators on the accuracy of phase-contrast velocimetry”. Journal of Magnetic Resonance. 2021; ‏ 325

Guan, D.Zhuan, X.Holmes, WLuo, X. and Gao, H. (2021) Modelling of fibre dispersion and its effects on cardiac mechanics from diastole to systole. Journal of Engineering Mathematics, 128, 1.



Alshuri MS, Gallagher L, McCabe C, Holmes WM. Changes in CSF dynamics responsible for Intracranial pressure elevation after ischemia stroke in rats: A new mechanism for unexplained END. Transl Stroke Res 2019 Aug 15

Javasekara G, Wilson KS, Buist H, Woodward R, Uckan A, Hughes C, Nilsen M, Church AC, Johnson MK, Gallagher L, Mullin JM, MacLean MR, Holmes WM, Peacock AJ, Welsh DJ (2020) Understanding longitudinal biventricular structural and functional changes in a pulmonary hypertension Sugen-hypoxia rat model by cardiac magnetic resonance imaging. Pulm. Circ. 10(1): 2045894019897513

Huber L, Finn ES, Handwerker DA, Boenstrup M, Glen D, Kashyap S, Ivanov D, Petridou N, Marrett S, Goense J, Poser BA, Bandettini PA (2020) Sub-millimeter fMRI reveals multiple topographic digit representations that form action maps in human motor cortex. NeuroImage 116463

Biose IJ, Dewar D, Macrae IM, McCabe C. Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke. J Cereb Blood Flow Metab 2020: 116463

Sampaio-Baptista C, Valles A, Khrapitcheb AA, Akkermans G, Winkler AM, Foxley S, Sibson NR, Roberts M, Miller K, Diamond ME, Martens GJM, De Weerd P, Johansen-Berg H. White matter structure and myelin-related gene expression alterations with experience in adult rats. Progress in Neurobiology 2020; 187, 101770



Al-Mubarak H, Vallatos A, Gallagher L, Birch JL, Gilmour L, Foster JE, Chalmers AJ, Holmes WM (2019) Stacked in-plane histology for quantitative validation of non-invasive imaging biomarkers: Application to an infiltrative brain tumour model. J Neurosci Methods 326:108372

Arroja MMC, Reid E, Roy LA, Vallatos AV, Holmes WM, Nicklin SA, Work LM, McCabe C. (2018) Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion. Sci Rep. 2019 Feb 28;9(1):3154. doi: 10.1038/s41598-019-39102-8

Jones FE, Murray LS, McNeilly S, Dean A, Aman A, Lu Y, Nikolova N, Malomgré R, Horsburgh K, Holmes WM, Kadler KE, Van Agtmael T. (2018) 4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease. Hum Mol Genet. 2019 Feb 15;28(4):628-638. doi: 10.1093/hmg/ddy369.

van Kralingen JC, McFall A, Ord ENJ, Coyle TF, Bissett M, McClure JD, McCabe C, Macrae IM, Dawson J, Work LM. Altered Extracellular Vesicle MicroRNA Expression in Ischemic Stroke and Small Vessel Disease. Transl Stroke Res. 2019 Jan 7. doi: 10.1007/s12975-018-0682-3. [Epub ahead of print]

Vallatos A, Al-Mubarak HFI, Birch JL, Gallagher L, Mullin JM, Gilmour L, Holmes WM, Chalmers AJ. Quantitative histopathologic assessment of perfusion MRI as a marker of glioblastoma cell infiltration in and beyond the peritumoral edema region. J Magn Reson Imaging. 2018 Dec 19. doi: 10.1002/jmri.26580.

Deuchar GA, van Kralingen JC, Work LM, Santosh C, Muir KW, McCabe C, Macrae IMPreclinical Validation of the Therapeutic Potential of Glasgow Oxygen Level Dependent (GOLD) Technology: a Theranostic for Acute Stroke. Translational Stroke Research, 2019 In Press



Zaldivar D, Rauch A, Logothetis NK, Goense J. (2018)  Two distinct profiles of fMRI and neurophysiological activity elicited by acetylcholine in visual cortex. Proc Natl Acad Sci USA. 2018 Dec 18;115(51):E12073-E12082. doi: 10.1073/pnas.1808507115.

Macrae IM, Allan SM (2018) Stroke: The past, present and future. Brain Neurosci Adv. 2018; 2:2398212818810689. doi: 10.1177/2398212818810689

Birch JL, Strathdee K, Gilmour L, Vallatos A, McDonald L, Kouzeli A, Vasan R, Qaisi AH, Croft DR, Crighton D, Gill K, Gray CH, Konczal J, Mezna M, McArthur D, Schüttelkopf AW, McConnell P, Sime M, Holmes WM, Bower J, McKinnon HJ, Drysdale M, Olson MF, Chalmers AJ (2018). A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma. Cancer Res. 2018 Nov 15;78(22):6509-6522. doi: 10.1158/0008-5472.CAN-18-1697

Vallatos A, Al-Mubarak HFI, Mullin JM, Holmes WM (2018) Accuracy of phase-contrast velocimetry in systems with skewed intravoxel velocity distributions. J Magn Reson 2018 Nov; 296: 121-129. doi: 10.1016/j.jmr.2018.09.002

Hietamies TM, Ostrowski C, Pei Z, Feng L, McCabe C, Work LM, Quinn TJ. (2018) Variability of functional outcome measures used in animal models of stroke and vascular cognitive impairment – a review of contemporary studies. J Cereb Blood Flow Metab. 2018 Nov; 38(11):1872-1884. doi: 10.1177/0271678X18799858

Grent-‘t-Jong T, Gross J, Goense J, Wibral M, Gajwani R, Gumley AI, Lawrie SM, Schwannauer M, Schultze-Lutter F, Navarro Schröder T, Koethe D, Leweke FM, Singer W, Uhlhaas PJ. (2018) Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages. Elife. 2018 Sep 27;7. pii: e37799. doi: 10.7554/eLife.37799

Goense J (2018) Resolving Memory Circuits with Layer-Dependent fMRI. Neuron. 2018 Sep 19;99(6):1107-1109. doi: 10.1016/j.neuron.2018.09.004

McCabe C, Arroja MM, Reid E, Macrae IM (2018). Animal models of ischaemic stroke and characterisation of the ischaemic penumbra. Neuropharmacology 2018. May 15; 134 (Pt B): 169-177. doi: 10.1016/j.neuropharm.2017.09.022

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O’Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8), pp. 851-868.

Deuchar GA, Brennan D, Holmes WM, Shaw M, Macrae IM, Santosh C (2018) Perfluorocarbon Enhanced Glasgow Oxygen Level Dependent (GOLD) magnetic resonance metabolic imaging identifies the penumbra following acute ischemic stroke. Theranostics, 8(6), pp. 1706-1722.

Merrifield GD, Brydges NM, Hall L, Mullin J, Gallagher L, Pizzi R, Holmes WM (2018) Measures of cardiac function in Theraphosidae spiders using in vivo magnetic resonance imaging. Physiological Entomology. 43(3), pp. 207-213

Vallatos A, Shukla MN, Mullin JM, Phoenix VR,  Holmes WM (2018)  The effect of displacement distribution asymmetry on accuracy of phase-shift velocimetry in porous media. Porous and Mesoporous Materials. 269, pp. 130-133

Vallatos A, Gilmour L, Chalmers AJ, Holmes WM. (2018).   Multiple boli Arterial Spin Labeling for high signal-to-noise rodent brain imaging. Magnetic Resonance in Medicine. 2018 Feb;79(2):1020-1030. doi: 10.1002/mrm.26706

Zaldivar, D., Goense, J., Lowe, S. C., Logothetis, N. K. and Panzeri, S. (2018) Dopamine is signaled by mid-frequency oscillations and boosts output-layers visual information in visual cortex. Current Biology. Jan 22;28(2):224-235.e5. doi: 10.1016/j.cub.2017.12.006.


Peer reviewed publications

Faller KM, Leach DG, Johnston P, Holmes WM, Macrae IM, Frenguelli BG (2017).  Proof of concept and feasibility studies examining the influence of combination ribose, adenine and allopurinol treatment on stroke outcome in the rat.  Brain and Neuroscience Advances.  1:1-13.

Merrifield GD, Mullin J, Gallagher L, Tucker C, Jansen MA, Denvir M, Holmes WM (2017) Rapid and recoverable in vivo magnetic resonance imaging of the adult zebrafish at 7 T. Magn Reson Imaging, Oct 14;37:9-15.

Percie du Sert N, Alfieri A, Allan SM, Carswell HV, Deuchar GA, Farr TD, Flecknell P, Gallagher L, Gibson CL, Haley MJ, Macleod MR, McColl BW, McCabe C, Morancho A, Moon LD, O’Neill MJ, Pérez de Puig I, Planas A, Ragan CI, Rosell A, Roy LA, Ryder KO, Simats A, Sena ES, Sutherland BA, Tricklebank MD, Trueman RC, Whitfield L, Wong R, Macrae IM.  (2017).  The IMPROVE Guidelines: (ischaemia models: procedural refinements of in vivo experiments). Journal of Cerebral Blood Flow and Metabolism. Jan 1:271678X17709185. doi: 10.1177/0271678X17709185.

Dani KA, Moreton FC, Santosh C, Lopez R, Brennan D, Schwarzbauer C, Goutcher C, O’Hare K, Macrae IM, Muir KW (2017) Oxygen challenge magnetic resonance imaging in healthy human volunteers. J Cereb Blood Flow Metab. 2017 Jan; 37(1):366-376

Arumugam T V, Manzanero S, Furtado M, Biggins PJ, Hsieh Y-H, Gelderblom M, MacDonald KP, Salimova E, Li Y-I, Korn O, Dewar D, Macrae IM, Ashman RB, Tang S-C, Rosenthal NA, Ruitenberg MJ, Magnus T, Wells CA (2017) An atypical role for the myeloid receptor Mincle in central nervous system injury. J Cereb Blood Flow Metab. Jun; 37(6): 2098-2111. doi: 10.1177/0271678X16661201.

Ku Mohd Noor KM, Wyse C, Roy LA, Biello SM, McCabe C, Dewar D. (2017) Chronic photoperiod disruption does not increase vulnerability to focal cerebral ischemia in young normotensive rats.  J Cereb Blood Flow Metab 37(11), pp. 3580-3588

Huber L, Handwerker DA, Jangraw DC, Chen G, Hall A, Stüber C, Gonzalez-Castillo J, Ivanov D, Marrett S, Guidi M, Goense J, Poser BA, Bandettini PA (2017) High-resolution CBV-fMRI allows mapping of laminar activity and connectivity of cortical input and output in human M1. Neuron.  Dec 20;96(6):1253-1263.e7. doi: 10.1016/j.neuron.2017.11.005.

Book Chapters & Review articles

McCabe C, Arroja MMC, Reid E & Macrae IM (2017). Animal Models of ischaemic stroke and characterisation of the ischaemic penumbra. Neuropharmacology.  2017 Sep 16. pii: S0028-3908(17)30439-2. doi: 10.1016/j.neuropharm.2017.09.022.

Zaldivar D, Logothetis NK, Rauch A, Goense J. Pharmaco-based MRI and neurophysiology in non-human primates (2017) In: In vivo Neuropharmacology and Neurophysiology. Springer Neuromethods Series. Eds. A Philippu

Demuth HU, Dijkhuizen RM, Farr TD, Gelderblom M, Horsburgh K, Iadecola C, Mcleod DD, Michalski D, Murphy TH, Orbe J, Otte WM, Petzold GC, Plesnila N, Reiser G, Reymann KG, Rueger MA, Saur D, Savitz SI, Schilling S, Spratt NJ, Turner RJ, Vemuganti R, Vivien D, Yepes M, Zille M, Boltze J; ISN&N meeting contributors (2017) Recent progress in translational research on neurovascular and neurodegenerative disorders. Restor Neurol Neurosci. 2017; 35(1):87-103. doi: 10.3233/RNN-160690.


Peer reviewed publications

Lopez Gonzalez MR, Foo SY, Holmes WM, Stewart W, Condon B, Muir KW, Welch G, Forbes KP. Atherosclerotic carotid plaque composition: a 3T and 7T MRI-histology correlation study. J Neuroimaging 2016, 26:406–413.

Milidonis X, Lennen RJ, Jansen MA, Mueller S, Boehm-Sturm P, Holmes WM, Sena ES, Macleod MR, Marshall I. Multicenter evaluation of geometric accuracy of MRI protocols used in experimental stroke. PLoS One 2016, Sep 7;11(9):e0162545

Lavery CA, Kurowska-Stolarska, Holmes WM, Donnelly I, Caslake M, Collier A, Baker AH, Miller AM  (2016).   miR-34a-/- mice are susceptible to diet-induced obesity. Obesity. 2016; 24(8): 1741-1751

Shukla MN, Vallatos A, Phoenix VR, Holmes WM. Accurate phase-shift velocimetry in rock. J Magn Reson 2016, 267:43–53.

Baskerville TA, Macrae IM, Holmes WM, McCabe C. The influence of gender on tissue at risk in acute stroke: A diffusion-weighted magnetic resonance imaging study in a rat model of focal cerebral ischaemia. J Cereb Blood Flow Metab 2016, 36:381–386.

Book Chapters & Review articles

Muir KW, Macrae IM. Neuroimaging as a selection tool and endpoint in preclinical and clinical trials. Transl Stroke Res 2016, 7:368–377.

Arroja MMC, Reid E, McCabe C. Therapeutic potential of the renin angiotensin system in ischaemic stroke. Exp Transl Stroke Med 2016, Oct 7: 8:8. doi: 10.1186/s13231-016-0022-1

McCabe C. Imaging the ischaemic penumbra with T2 weighted MRI. J Cereb Blood Flow Metab 2016, 36.

Goense J, Bohraus Y, Logothetis NK. fMRI at high spatial resolution: Implications for BOLD-models. Front Comput Neurosci 2016, 10:66.


Peer reviewed publications

Lakshmanan S, Holmes WM, Sloan WT, Phoenix VR. Characterization of nanoparticle transport through quartz and dolomite gravels by magnetic resonance imaging. Int J Environ Sci Technol 2015, 12:3373–3384.

Murtha LA, McLeod DD, Pepperall D, McCann SK, Beard DJ, Tomkins AJ, Holmes WM, McCabe C, Macrae IM, Spratt NJ. Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy. J Cereb Blood Flow Metab 2015, 35:592–600.

Huber L, Goense J, Kennerley AJ, Trampel R, Guidi M, Reimer E, Ivanov D, Neef N, Gauthier CJ, Turner R, Möller HE. Cortical lamina-dependent blood volume changes in human brain at 7T. Neuroimage 2015, 107:23–33.

Wetterling F, Gallagher L, Mullin J, Holmes WM, McCabe C, Macrae IM, Fagan AJ. Sodium-23 magnetic resonance imaging has potential for improving penumbra detection but not for estimating stroke onset time. J Cereb Blood Flow Metab 2015 Jan; 35(1): 103-10. doi: 10.1038/jcbfm.2014.174.

Robertson CA, McCabe C, Lopez-Gonzalez MR, Deuchar GA, Dani K, Holmes WM, Muir KW, Santosh C, Macrae IM. Detection of ischemic penumbra using combined perfusion and T2* oxygen challenge imaging. Int J Stroke 2015 Jan; 10(1):42-50. doi: 10.1111/ijs.12327.

Book Chapters & Review articles

Campbell BCV, Macrae IM. Translational perspectives on perfusion-diffusion mismatch in ischemic stroke. Int J Stroke 2015 Feb; 10(2): 153-62. doi: 10.1111/ijs.12186.


Peer reviewed publications

Mazen MM, MacLellan S, Dufes C, Holmes WM, Condon B, Uchegbu IF, Schatzlein AG. Size-tuneable nanometric MRI contrast agents for the imaging of molecular weight dependent transport processes. Pharm Nanotechnol 2014, 2:129–137.

Murray KN, Girard S, Holmes WM, Parkes LM, Williams SR, Parry-Jones AR, Allan SM. Systemic inflammation impairs tissue reperfusion through endothelin-dependent mechanisms in cerebral ischemia. Stroke 2014, 45:3412–3419.

Huber L, Goense J, Kennerley AJ, Ivanov D, Krieger SN, Lepsien J, Trampel R, Turner R, Möller HE. Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7T. Neuroimage 2014, 97:349–362.

Zaldivar D, Rauch A, Whittingstall K, Logothetis NK, Goense J. Dopamine-induced dissociation of BOLD and neural activity in macaque visual cortex. Curr Biol 2014, 24:2805–2811.


Peer reviewed publications

Baron J-C, Macrae IM, Adams HP, Dirnagl U. ESC-BRAIN: experimental and clinical stroke research – do they connect? Cerebrovasc Dis 2013, 36:306–321.

Brittain JF, McCabe C, Khatun H, Kaushal N, Bridges LR, Holmes WM, Barrick TR, Graham D, Dominiczak AF, Macrae IM, Hainsworth AH. An MRI-histological study of white matter in stroke-free SHRSP. J Cereb Blood Flow Metab 2013, 33:760–763.

Deuchar GA, Brennan D, Griffiths H, Macrae IM, Santosh C. Perfluorocarbons enhance a T2*-based MRI technique for identifying the penumbra in a rat model of acute ischemic stroke. J Cereb Blood Flow Metab 2013, 33:1422–1428.

Howard LE, Holmes WM, Ferrando S, Maclaine JS, Kelsh RN, Ramsey A, Abel RL, Cox JPL. Functional nasal morphology of chimaerid fishes. J Morphol 2013, 274:987–1009.

Ord ENJ, Shirley R, McClure JD, McCabe C, Kremer EJ, Macrae IM, Work LM. Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats. J Cereb Blood Flow Metab 2013, 33:1215–1224.

Ramanan B, Holmes WM, Sloan WT, Phoenix VR. Magnetic resonance imaging of mass transport and structure inside a phototrophic biofilm. Curr Microbiol 2013, 66:456–461.

Tarr D, Graham D, Roy LA, Holmes WM, McCabe C, Macrae IM, Muir KW, Dewar D. Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. J Cereb Blood Flow Metab 2013, 33:1556–1563.

Book Chapters & Review articles

Baron JC, Macrae IM, Adams HP Jr, Dirnagl U. ESC-BRAIN: experimental and clinical stroke research–do they connect?. Meeting report of the ESC-BRAIN joint symposium held in London and Shanghai in May 2013. Cerebrovasc Dis. 2013;36(4):306-21. doi: 10.1159/000355027.


Peer reviewed publications

Baskerville TA, McCabe C, Weir CJ, Macrae IM, Holmes WM. Noninvasive MRI measurement of CBF: Evaluating an arterial spin labelling sequence with 99mTc-HMPAO CBF autoradiography in a rat stroke model. J Cereb Blood Flow Metab 2012, Jun;32(6):973-7.

Bingham D, Martin SJ, Macrae IM, Carswell HVO. Watermaze performance after middle cerebral artery occlusion in the rat: the role of sensorimotor versus memory impairments. J Cereb Blood Flow Metab 2012, 32:989–999.

Goense J, Merkle H, Logothetis NK. High-resolution fMRI reveals laminar differences in neurovascular coupling between positive and negative BOLD responses. Neuron 2012, 76:629–639.

Haynes H, Ockelford A-M, Vignaga E, Holmes WM. A new approach to define surface/sub-surface transition in gravel beds. Acta Geophys 2012, 60:1589–1606.

Holmes WM, Lopez-Gonzalez MR, Gallagher L, Deuchar G, Macrae I, Santosh C. Novel MRI detection of the ischemic penumbra: direct assessment of metabolic integrity. NMR Biomed 2012, 25:295–304.

Ord ENJ, Shirley R, van Kralingen JC, Graves A, McClure JD, Wilkinson M, McCabe C, Macrae IM, Work LM. Positive impact of pre-stroke surgery on survival following transient focal ischemia in hypertensive rats. J Neurosci Methods 2012, 211:305–308.

Ramanan B, Holmes WM, Sloan WT, Phoenix VR. Investigation of nanoparticle transport inside coarse-grained geological media using magnetic resonance imaging. Environ Sci Technol 2012, 46:360–366.

Reid E, Graham D, Lopez-Gonzalez MR, Holmes WM, Macrae IM, McCabe C. Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. J Cereb Blood Flow Metab 2012, 32:1765–1777.

Wetterling F, Gallagher L, Macrae IM, Junge S, Fagan AJ. Regional and temporal variations in tissue sodium concentration during the acute stroke phase. Magn Reson Med 2012, 67:740–749.

Wetterling F, Hogler M, Molkenthin U, Junge S, Gallagher L, Macrae IM, Fagan AJ. The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI. J Magn Reson 2012, 217:10–18.

Goense J, Whittingstall K, Logothetis NK. Neural and BOLD responses across the brain. Wiley Interdiscip Rev Cogn Sci 2012, 3:75–86.

Stoewer S, Goense J, Keliris GA, Bartels A, Logothetis NK, Duncan J, Sigala N. An Analysis Approach for high-field fMRI data from awake non-human primates. PLoS One 2012, 7:e29697.

von Pföstl V, Li J, Zaldivar D, Goense J, Zhang X, Serr N, Logothetis NK, Rauch A. Effects of lactate on the early visual cortex of non-human primates, investigated by pharmaco-MRI and neurochemical analysis. Neuroimage 2012, 61:98–105.

Book Chapters & Review articles

Haynes H, Holmes WM. Imaging sediment structure: the emerging use of Magnetic Resonance Imaging (MRI) for 3D analysis of sediment structures and internal flow processes. In Geomorphological Techniques. Edited by Clarke LE. London: British Society for Geomorphology; 2012.

Bartels A, Goense J, Logothetis N. An introduction to functional Magnetic Resonance Imaging (fMRI) and the origin of the blood oxygen level dependent (BOLD) signal. In: Handbook of Neural Activity Measurement. Cambridge University Press, Cambridge, UK. Eds. R Brette & A Destexhe. (publication date 31 October 2012)


Peer reviewed publications

Baskerville T, Deuchar GA, McCabe C, Robertson CA, Holmes WM, Santosh C, Macrae IM. Influence of 100% and 40% oxygen on penumbral blood flow, oxygen level, and T2*-weighted MRI in a rat stroke model. J Cereb Blood Flow Metab 2011, 31:1799–1806.

Holmes WM, Cotton R, Xuan VB, Rygg AD, Craven BA, Abel RL, Slack R, Cox JPL. Three-dimensional structure of the nasal passageway of a hagfish and its implications for olfaction. Anat Rec Adv Integr Anat Evol Biol 2011, 294:1045–1056.

Ku S, Tolias AS, Logothetis NK, Goense J. fMRI of the face-processing network in the ventral temporal lobe of awake and anesthetized macaques. Neuron 2011, 70:352–362.

Stoewer S, Goense J, Keliris GA, Bartels A, Logothetis NK, Duncan J, Sigala N. Realignment strategies for awake-monkey fMRI data. Magn Reson Imaging 2011, 29:1390–1400.

Moldrich RX, Mezzera C, Holmes WM, Goda S, Brookfield SJ, Rankin AJ, Barr E, Kurniawan N, Dewar D, Richards LJ, Lopez-Bendito G, Iwata T. Fgfr3 regulates development of the caudal telencephalon. Dev Dyn 2011, 240:1586–1599.

Robertson CA, McCabe C, Gallagher L, Lopez Gonzalez M del, Holmes WM, Condon B, Muir KW, Santosh C, Macrae IM. Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion. J Cereb Blood Flow Metab 2011, 31:1788–1798.

Robertson CA, McCabe C, Gallagher L, Lopez-Gonzalez M del, Holmes WM, Condon B, Muir KW, Santosh C, Macrae IM. Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography. J Cereb Blood Flow Metab 2011, 31:1778–1787.

Rodgers J, Jones A, Gibaud S, Bradley B, McCabe C, Barrett MP, Gettinby G, Kennedy PGE. Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Negl Trop Dis 2011, Sep;5(9):e1308.

Rodgers J, McCabe C, Gettinby G, Bradley B, Condon B, Kennedy PGE. Magnetic resonance imaging to assess blood-brain barrier damage in murine trypanosomiasis. Am J Trop Med Hyg 2011, Feb;84(2):344-50.

Ruest T, Holmes WM, Barrie JA, Griffiths IR, Anderson TJ, Dewar D, Edgar JM. High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR Biomed 2011, 24:1369–1379.

Book Chapters & Review articles

Macrae IM. Preclinical stroke research – advantages and disadvantages of the most common rodent models of focal ischaemia. Br J Pharmacol 2011, 164:1062–1078.


Peer reviewed publications

Dani KA, Santosh C, Brennan D, McCabe C, Holmes WM, Condon B, Hadley DM, Macrae IM, Shaw M, Muir KW. T2*-weighted magnetic resonance imaging with hyperoxia in acute ischemic stroke. Ann Neurol 2010, 68:37–47.

Logothetis NK, Augath M, Murayama Y, Rauch A, Sultan F, Goense J, Oeltermann A, Merkle H. The effects of electrical microstimulation on cortical signal propagation. Nat Neurosci 2010, 13:1283–1291.

McCabe C, Gallagher L, Macrae IM, Gsell W, Graham D, Dominiczak AF. Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke 2010, 41:E198–E199.

Miller AM, Asquith DL, Hueber AJ, Anderson LA, Holmes WM, McKenzie AN, Xu D, Sattar N, McInnes IB, Liew FY. Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice. Circulation Research 2010, 107:650–658.

Ramanan B, Holmes WM, Sloan WT, Phoenix VR. Application of paramagnetically tagged molecules for magnetic resonance imaging of biofilm mass transport processes. Appl Environ Microbiol 2010, 76:4027–4036.

Wetterling F, Tabbert M, Junge S, Gallagher L, Macrae IM, Fagan AJ. A double-tuned 1H/23Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI. Phys Med Biol 2010, 55:7681–7695.

Goense J, Whittingstall K, Logothetis NK. Functional magnetic resonance imaging of awake behaving macaques. Methods 2010, 50:178–188.

Goense J, Logothetis NK, Merkle H. Flexible, phase-matched, linear receive arrays for high-field MRI in monkeys. Magn Reson Imaging 2010, 28:1183–1191.

Book Chapters & Review articles

Goense J, Logothetis NK. Physiological basis of the BOLD signal. In: Simultaneous EEG and fMRI: recording, analysis and applications. Oxford University Press, Eds. M Ullsperger & S Debener (publication date 28 May 2010)


Peer reviewed publications

Haynes H, Vignaga E, Holmes WM. Using magnetic resonance imaging for experimental analysis of fine-sediment infiltration into gravel beds. Sedimentology 2009, 56:1961–1975.

Holmes WM, McCabe C, Mullin JM, Condon B, Bain MM. In ovo non-invasive quantification of the myocardial function and mass of chick embryos using magnetic resonance imaging. NMR Biomed 2009, Aug;22(7):745-52.

McCabe C, Gallagher L, Gsell W, Graham D, Dominiczak AF, Macrae IM. Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke 2009, 40:3864–3868.

Book Chapters & Review articles

Shah IM, Macrae IM, Di Napoli M. Neuroinflammation and Neuroprotective Strategies in Acute Ischaemic Stroke – from bench to bedside. Curr Mol Med 2009, 9:336–354.


Peer reviewed publications

Fagan AJ, Mullin JM, Gallagher L, Hadley DM, Macrae IM, Condon B. Serial postmortem relaxometry in the normal rat brain and following stroke. J Magn Reson Imaging 2008, 27:469–475.

Farr TD, Carswell HVO, Mccann DJ, Sato M, Bryant HU, Dodge JA, Macrae IM. The selective oestrogen receptor modulator, LY362321, is not neuroprotective in a rat model of transient focal ischaemia. J Neuroendocrinol 2008, 20:366–374.

Goense J, Logothetis NK. Neurophysiology of the BOLD fMRI signal in awake monkeys. Current Biol 2008, 18:631–640.

Holmes WM, Maclellan S, Condon B, Dufes C, Evans TR, Uchegbu IF, Schatzlein AG. High-resolution 3D isotropic MR imaging of mouse flank tumours obtained in vivo with solenoid RF micro-coil. Phys Med Biol 2008, 53:505–513.

Holmes WM, McCabe C, Mullin JM, Condon B, Bain MM. Noninvasive self-gated magnetic resonance cardiac imaging of developing chick embryos in ovo. Circulation 2008, 117:E346–E347.

Lecrux C, McCabe C, Weir CJ, Gallagher L, Mullin J, Touzani O, Muir K, Lees KR, Macrae IM. Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats. Stroke 2008, 39:448–454.

Zappe AC, Pfeuffer J, Merkle H, Logothetis NK, Goense J. The effect of labeling parameters on perfusion-based fMRI in nonhuman primates. J Cereb Blood Flow Metab 2008, 28:640–652.

McCabe C, White F, Brown SM, Macrae IM. GADD34 gene restores virulence in viral vector used in experimental stroke study. J Cereb Blood Flow Metab 2008, 28:747–751.

Goense J, Ku S-P, Merkle H, Tolias AS, Logothetis NK. fMRI of the temporal lobe of the awake monkey at 7 T. Neuroimage 2008, 39:1081–1093.

Goense J, Logothetis NK. Neurophysiology of the BOLD fMRI signal in awake monkeys. Curr Biol 2008, 18:631–640.

Op de Beeck HP, DiCarlo JJ, Goense J, Grill-Spector K, Papanastassiou A, Tanifuji M, Tsao DY. Fine-scale spatial organization of face and object selectivity in the temporal lobe: do functional magnetic resonance imaging, optical imaging, and electrophysiology agree? J Neurosci 2008, 28:11796–11801.

Phoenix VR, Holmes WM. Magnetic resonance imaging of structure, diffusivity, and copper immobilization in a phototrophic biofilm. Appl Environ Microbiol 2008, 74:4934–4943.

Santosh C, Brennan D, McCabe C, Macrae IM, Holmes WM, Graham DI, Gallagher L, Condon B, Hadley DM, Muir KW, Gsell W. Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. J Cereb Blood Flow Metab 2008, 28:1742–1753.


Peer reviewed publications

Farr TD, Carswell HVO, Gsell W, Macrae IM. Estrogen receptor beta agonist diarylpropiolnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia. Brain Res 2007, 1185:275–282.

Bain MM, Fagan AJ, Mullin JM, McNaught I, McLean J, Condon B. Noninvasive monitoring of chick development in ovo using a 7T MRI system from day 12 of incubation through to hatching. J Magn Reson Imaging 2007, 26:198–201.

Price A, Lockhart JC, Ferrell WR, Gsell W, McLean S, Sturrock RD. Angiotensin II type 1 receptor as a novel therapeutic target in rheumatoid arthritis: In vivo analyses in rodent models of arthritis and ex vivo analyses in human inflammatory synovitis. Arthritis Rheum 2007, 56:441–447.

Goense J, Zappe A-C, Logothetis NK. High-resolution fMRI of macaque V1. Magn Reson Imaging 2007, 25:740–747.


Peer reviewed publications

Farr TD, Carswell HVO, Gallagher L, Condon B, Fagan AJ, Mullin J, Macrae IM. 17 beta-estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function. Neurobiol Dis 2006, 23:552–562.

Lopez-Gonzalez MR, Holmes WM, Callaghan PT. Rheo-NMR phenomena of wormlike micelles. Soft Matter 2006, 2:855–869.

Goense J, Logothetis NK. Laminar specificity in monkey V1 using high resolution SE-fMRI. Magnetic Resonance Imaging 2006, 24(4): 381-392