Spontaneous stroke in the Stroke Prone Spontaneously Hypertensive Rat (SHRSP)

3 images showing the Blood brain barrier breakdown following spontaneous stroke in the aged SHRSP rat. 1 and 2. T1 weighed images showing the pre and post contrast uptake within the cortex. and 3. a T2 weighted image showing hyperintense region caused by ischaemic damage.

Blood brain barrier breakdown showing uptake of Gadolinium contrast agent following spontaneous stroke in the aged SHRSP rat (T1 weighed post contrast image: left, arrow highlights hyperintensity showing contrast agent uptake within the cortex; middle). Representative T2 weighted image showing hyperintense region caused by ischaemic damage (right).

6 images showing a Spontaneous stroke on a 10 month hypertensive rat.

Relevant References:

Brittain, J.F., McCabe, C., Khatun, H., Kaushal, N., Bridges, L.R., Holmes, W.M., Barrick, T.R., Graham, D., Dominiczak, A.F., Macrae, I.M & Hainsworth, A.H. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33 (5). pp. 760-763. ISSN 0271-678X (doi:10.1038/jcbfm.2013.14)